Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials.
Identifieur interne : 000162 ( Main/Exploration ); précédent : 000161; suivant : 000163Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials.
Auteurs : Dirk Schadendorf [Allemagne] ; Georgina V. Long [Australie] ; Daniil Stroiakovski [Russie] ; Boguslawa Karaszewska [Pologne] ; Axel Hauschild [Allemagne] ; Evgeny Levchenko [Russie] ; Vanna Chiarion-Sileni [Italie] ; Jacob Schachter [Israël] ; Claus Garbe [Allemagne] ; Caroline Dutriaux [France] ; Helen Gogas [Grèce] ; Mario Mandalà [Italie] ; John B A G. Haanen [Pays-Bas] ; Céleste Lebbé [France] ; Andrzej Mackiewicz [Pologne] ; Piotr Rutkowski [Pologne] ; Jean-Jacques Grob [France] ; Paul Nathan [Royaume-Uni] ; Antoni Ribas [États-Unis] ; Michael A. Davies [États-Unis] ; Ying Zhang [États-Unis] ; Mathilde Kaper [États-Unis] ; Bijoyesh Mookerjee [États-Unis] ; Jeffrey J. Legos [États-Unis] ; Keith T. Flaherty [États-Unis] ; Caroline Robert [France]Source :
- European journal of cancer (Oxford, England : 1990) [ 1879-0852 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de survie, Facteurs de risque, Femelle, Humains, Imidazoles (administration et posologie), Inhibiteurs de protéines kinases (usage thérapeutique), L-Lactate dehydrogenase (métabolisme), Mâle, Mélanome (anatomopathologie), Mélanome (métabolisme), Mélanome (traitement médicamenteux), Métastase tumorale (anatomopathologie), Oximes (administration et posologie), Pronostic, Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Pyridones (administration et posologie), Pyrimidinones (administration et posologie), Sujet âgé, Valeur prédictive des tests.
- MESH :
- administration et posologie : Imidazoles, Oximes, Pyridones, Pyrimidinones.
- anatomopathologie : Mélanome, Métastase tumorale.
- métabolisme : L-Lactate dehydrogenase, Mélanome.
- traitement médicamenteux : Mélanome.
- usage thérapeutique : Inhibiteurs de protéines kinases, Protocoles de polychimiothérapie antinéoplasique.
- Adulte, Adulte d'âge moyen, Analyse de survie, Facteurs de risque, Femelle, Humains, Mâle, Pronostic, Sujet âgé, Valeur prédictive des tests.
English descriptors
- KwdEn :
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Female, Humans, Imidazoles (administration & dosage), L-Lactate Dehydrogenase (metabolism), Male, Melanoma (drug therapy), Melanoma (metabolism), Melanoma (pathology), Middle Aged, Neoplasm Metastasis (pathology), Oximes (administration & dosage), Predictive Value of Tests, Prognosis, Protein Kinase Inhibitors (therapeutic use), Pyridones (administration & dosage), Pyrimidinones (administration & dosage), Risk Factors, Survival Analysis.
- MESH :
- chemical , administration & dosage : Imidazoles, Oximes, Pyridones, Pyrimidinones.
- chemical , metabolism : L-Lactate Dehydrogenase.
- drug therapy : Melanoma.
- metabolism : Melanoma.
- pathology : Melanoma, Neoplasm Metastasis.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols, Protein Kinase Inhibitors.
- Adult, Aged, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Risk Factors, Survival Analysis.
Abstract
Understanding predictors of long-term benefit with currently available melanoma therapies is the key for optimising individualised treatments. A prior pooled analysis of dabrafenib plus trametinib (D + T)-randomised trials (median follow-up, 20.0 months) identified baseline lactate dehydrogenase (LDH) and number of organ sites with metastasis as predictive factors for progression-free (PFS) and overall (OS) survival. However, longer-term follow-up analyses are needed to confirm which patients treated with D + T can achieve maximum benefit.
DOI: 10.1016/j.ejca.2017.05.033
PubMed: 28648698
Affiliations:
- Allemagne, Australie, France, Grèce, Israël, Italie, Pays-Bas, Pologne, Royaume-Uni, Russie, États-Unis
- Bade-Wurtemberg, Californie, District de Karlsruhe, District de Tübingen, District fédéral central, Massachusetts, New Jersey, Nouvelle-Galles du Sud, Schleswig-Holstein, Texas, Île-de-France
- Heidelberg, Kiel, Moscou, Paris, Sydney, Tübingen
- Université de Sydney
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Merge: 004A38
- to stream Ncbi, to step Curation: 004A38
- to stream Ncbi, to step Checkpoint: 004A38
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Le document en format XML
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Hôpital Saint-André, 1 Rue Jean Burguet, 33000 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Dermatologie et Dermatologie Pédiatrique, Hôpital Saint-André, 1 Rue Jean Burguet, 33000 Bordeaux</wicri:regionArea><wicri:noRegion>33000 Bordeaux</wicri:noRegion><wicri:noRegion>33000 Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Gogas, Helen" sort="Gogas, Helen" uniqKey="Gogas H" first="Helen" last="Gogas">Helen Gogas</name><affiliation wicri:level="1"><nlm:affiliation>First Department of Medicine, "Laiko" General Hospital, National and Kapodistrian University of Athens, Athens 157 72, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Medicine, "Laiko" General Hospital, National and Kapodistrian University of Athens, Athens 157 72</wicri:regionArea><wicri:noRegion>Athens 157 72</wicri:noRegion></affiliation></author><author><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandalà">Mario Mandalà</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Haanen, John B A G" sort="Haanen, John B A G" uniqKey="Haanen J" first="John B A G" last="Haanen">John B A G. Haanen</name><affiliation wicri:level="1"><nlm:affiliation>Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam</wicri:regionArea><wicri:noRegion>1066 CX Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Lebbe, Celeste" sort="Lebbe, Celeste" uniqKey="Lebbe C" first="Céleste" last="Lebbé">Céleste Lebbé</name><affiliation wicri:level="3"><nlm:affiliation>APHP Dermatology and CIC Departments, INSERM U976, University Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHP Dermatology and CIC Departments, INSERM U976, University Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mackiewicz, Andrzej" sort="Mackiewicz, Andrzej" uniqKey="Mackiewicz A" first="Andrzej" last="Mackiewicz">Andrzej Mackiewicz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Immunology, Poznan University of Medical Sciences, 15 Garbary Street, 61-866 Poznań, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cancer Immunology, Poznan University of Medical Sciences, 15 Garbary Street, 61-866 Poznań</wicri:regionArea><wicri:noRegion>61-866 Poznań</wicri:noRegion></affiliation></author><author><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Wawelska 15B, 02-034 Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Wawelska 15B, 02-034 Warsaw</wicri:regionArea><wicri:noRegion>02-034 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Grob, Jean Jacques" sort="Grob, Jean Jacques" uniqKey="Grob J" first="Jean-Jacques" last="Grob">Jean-Jacques Grob</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, University Hospital Center, Timone Hospital, Aix Marseille University, 264 Rue St Pierre, 13885 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, University Hospital Center, Timone Hospital, Aix Marseille University, 264 Rue St Pierre, 13885 Marseille Cedex 05</wicri:regionArea><wicri:noRegion>13885 Marseille Cedex 05</wicri:noRegion><wicri:noRegion>13885 Marseille Cedex 05</wicri:noRegion></affiliation></author><author><name sortKey="Nathan, Paul" sort="Nathan, Paul" uniqKey="Nathan P" first="Paul" last="Nathan">Paul Nathan</name><affiliation wicri:level="1"><nlm:affiliation>Mount Vernon Cancer Centre, Rickmansworth Road, HA6 2RN Northwood, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Mount Vernon Cancer Centre, Rickmansworth Road, HA6 2RN Northwood</wicri:regionArea><wicri:noRegion>HA6 2RN Northwood</wicri:noRegion></affiliation></author><author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Hematology/Oncology, UCLA Medical Center, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Hematology/Oncology, UCLA Medical Center, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Davies, Michael A" sort="Davies, Michael A" uniqKey="Davies M" first="Michael A" last="Davies">Michael A. Davies</name><affiliation wicri:level="2"><nlm:affiliation>Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston 77030, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston 77030, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Kaper, Mathilde" sort="Kaper, Mathilde" uniqKey="Kaper M" first="Mathilde" last="Kaper">Mathilde Kaper</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Mookerjee, Bijoyesh" sort="Mookerjee, Bijoyesh" uniqKey="Mookerjee B" first="Bijoyesh" last="Mookerjee">Bijoyesh Mookerjee</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Legos, Jeffrey J" sort="Legos, Jeffrey J" uniqKey="Legos J" first="Jeffrey J" last="Legos">Jeffrey J. Legos</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Flaherty, Keith T" sort="Flaherty, Keith T" uniqKey="Flaherty K" first="Keith T" last="Flaherty">Keith T. Flaherty</name><affiliation wicri:level="2"><nlm:affiliation>Developmental Therapeutics and Melanoma Programs, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston 02114, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Developmental Therapeutics and Melanoma Programs, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston 02114, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Dermatology Service, Gustave Roussy Comprehensive Cancer Center and Faculty of Medicine, University Paris-South, F-94805, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Dermatology Service, Gustave Roussy Comprehensive Cancer Center and Faculty of Medicine, University Paris-South, F-94805, Villejuif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Villejuif</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28648698</idno><idno type="pmid">28648698</idno><idno type="doi">10.1016/j.ejca.2017.05.033</idno><idno type="wicri:Area/PubMed/Corpus">000642</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000642</idno><idno type="wicri:Area/PubMed/Curation">000640</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000640</idno><idno type="wicri:Area/PubMed/Checkpoint">000640</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000640</idno><idno type="wicri:Area/Ncbi/Merge">004A38</idno><idno type="wicri:Area/Ncbi/Curation">004A38</idno><idno type="wicri:Area/Ncbi/Checkpoint">004A38</idno><idno type="wicri:Area/Main/Merge">000157</idno><idno type="wicri:Area/Main/Curation">000162</idno><idno type="wicri:Area/Main/Exploration">000162</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Three-year pooled analysis of factors associated with clinical outcomes across dabrafenib and trametinib combination therapy phase 3 randomised trials.</title><author><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany; German Cancer Consortium, 69117 Heidelberg, Germany. Electronic address: Dirk.Schadendorf@uk-essen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany; German Cancer Consortium, 69117 Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Long, Georgina V" sort="Long, Georgina V" uniqKey="Long G" first="Georgina V" last="Long">Georgina V. Long</name><affiliation wicri:level="4"><nlm:affiliation>Melanoma Institute Australia, The University of Sydney, NSW, Australia; Mater Hospital, North Sydney, NSW, Australia; Royal North Shore Hospital, St Leonards, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melanoma Institute Australia, The University of Sydney, NSW, Australia; Mater Hospital, North Sydney, NSW, Australia; Royal North Shore Hospital, St Leonards, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Stroiakovski, Daniil" sort="Stroiakovski, Daniil" uniqKey="Stroiakovski D" first="Daniil" last="Stroiakovski">Daniil Stroiakovski</name><affiliation wicri:level="1"><nlm:affiliation>Moscow City Oncology Hospital No 62, Moscow 143423, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow City Oncology Hospital No 62, Moscow 143423</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Karaszewska, Boguslawa" sort="Karaszewska, Boguslawa" uniqKey="Karaszewska B" first="Boguslawa" last="Karaszewska">Boguslawa Karaszewska</name><affiliation wicri:level="1"><nlm:affiliation>Przychodnia Lekarska KOMED, Wojska Polskiego 6, 62-500 Konin, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Przychodnia Lekarska KOMED, Wojska Polskiego 6, 62-500 Konin</wicri:regionArea><wicri:noRegion>62-500 Konin</wicri:noRegion></affiliation></author><author><name sortKey="Hauschild, Axel" sort="Hauschild, Axel" uniqKey="Hauschild A" first="Axel" last="Hauschild">Axel Hauschild</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Medical Center Schleswig-Holstein, Arnold-Heller-Straße 3, 24105 Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Medical Center Schleswig-Holstein, Arnold-Heller-Straße 3, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Levchenko, Evgeny" sort="Levchenko, Evgeny" uniqKey="Levchenko E" first="Evgeny" last="Levchenko">Evgeny Levchenko</name><affiliation wicri:level="1"><nlm:affiliation>Petrov Research Institute of Oncology, 68 Leningradskaya Street, Saint Petersburg 197758, Russia.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Petrov Research Institute of Oncology, 68 Leningradskaya Street, Saint Petersburg 197758</wicri:regionArea><wicri:noRegion>Saint Petersburg 197758</wicri:noRegion></affiliation></author><author><name sortKey="Chiarion Sileni, Vanna" sort="Chiarion Sileni, Vanna" uniqKey="Chiarion Sileni V" first="Vanna" last="Chiarion-Sileni">Vanna Chiarion-Sileni</name><affiliation wicri:level="1"><nlm:affiliation>Melanoma and Esophageal Oncology Unit, Veneto Oncology Institute-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Melanoma and Esophageal Oncology Unit, Veneto Oncology Institute-IRCCS, Via Gattamelata 64, 35128 Padova</wicri:regionArea><wicri:noRegion>35128 Padova</wicri:noRegion></affiliation></author><author><name sortKey="Schachter, Jacob" sort="Schachter, Jacob" uniqKey="Schachter J" first="Jacob" last="Schachter">Jacob Schachter</name><affiliation wicri:level="1"><nlm:affiliation>Oncology Division, Sheba Medical Center, Tel HaShomer, Emek HaEla St 1, Ramat Gan, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Oncology Division, Sheba Medical Center, Tel HaShomer, Emek HaEla St 1, Ramat Gan</wicri:regionArea><wicri:noRegion>Ramat Gan</wicri:noRegion></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University of Tübingen, Geschwister-Scholl-Platz, 72074 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name><affiliation wicri:level="1"><nlm:affiliation>Service de Dermatologie et Dermatologie Pédiatrique, Hôpital Saint-André, 1 Rue Jean Burguet, 33000 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Dermatologie et Dermatologie Pédiatrique, Hôpital Saint-André, 1 Rue Jean Burguet, 33000 Bordeaux</wicri:regionArea><wicri:noRegion>33000 Bordeaux</wicri:noRegion><wicri:noRegion>33000 Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Gogas, Helen" sort="Gogas, Helen" uniqKey="Gogas H" first="Helen" last="Gogas">Helen Gogas</name><affiliation wicri:level="1"><nlm:affiliation>First Department of Medicine, "Laiko" General Hospital, National and Kapodistrian University of Athens, Athens 157 72, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Medicine, "Laiko" General Hospital, National and Kapodistrian University of Athens, Athens 157 72</wicri:regionArea><wicri:noRegion>Athens 157 72</wicri:noRegion></affiliation></author><author><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandalà">Mario Mandalà</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo</wicri:regionArea><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Haanen, John B A G" sort="Haanen, John B A G" uniqKey="Haanen J" first="John B A G" last="Haanen">John B A G. Haanen</name><affiliation wicri:level="1"><nlm:affiliation>Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam</wicri:regionArea><wicri:noRegion>1066 CX Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Lebbe, Celeste" sort="Lebbe, Celeste" uniqKey="Lebbe C" first="Céleste" last="Lebbé">Céleste Lebbé</name><affiliation wicri:level="3"><nlm:affiliation>APHP Dermatology and CIC Departments, INSERM U976, University Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHP Dermatology and CIC Departments, INSERM U976, University Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mackiewicz, Andrzej" sort="Mackiewicz, Andrzej" uniqKey="Mackiewicz A" first="Andrzej" last="Mackiewicz">Andrzej Mackiewicz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Immunology, Poznan University of Medical Sciences, 15 Garbary Street, 61-866 Poznań, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cancer Immunology, Poznan University of Medical Sciences, 15 Garbary Street, 61-866 Poznań</wicri:regionArea><wicri:noRegion>61-866 Poznań</wicri:noRegion></affiliation></author><author><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Wawelska 15B, 02-034 Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Wawelska 15B, 02-034 Warsaw</wicri:regionArea><wicri:noRegion>02-034 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Grob, Jean Jacques" sort="Grob, Jean Jacques" uniqKey="Grob J" first="Jean-Jacques" last="Grob">Jean-Jacques Grob</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, University Hospital Center, Timone Hospital, Aix Marseille University, 264 Rue St Pierre, 13885 Marseille Cedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, University Hospital Center, Timone Hospital, Aix Marseille University, 264 Rue St Pierre, 13885 Marseille Cedex 05</wicri:regionArea><wicri:noRegion>13885 Marseille Cedex 05</wicri:noRegion><wicri:noRegion>13885 Marseille Cedex 05</wicri:noRegion></affiliation></author><author><name sortKey="Nathan, Paul" sort="Nathan, Paul" uniqKey="Nathan P" first="Paul" last="Nathan">Paul Nathan</name><affiliation wicri:level="1"><nlm:affiliation>Mount Vernon Cancer Centre, Rickmansworth Road, HA6 2RN Northwood, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Mount Vernon Cancer Centre, Rickmansworth Road, HA6 2RN Northwood</wicri:regionArea><wicri:noRegion>HA6 2RN Northwood</wicri:noRegion></affiliation></author><author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Hematology/Oncology, UCLA Medical Center, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Hematology/Oncology, UCLA Medical Center, 100 UCLA Medical Plaza, Suite 550, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Davies, Michael A" sort="Davies, Michael A" uniqKey="Davies M" first="Michael A" last="Davies">Michael A. Davies</name><affiliation wicri:level="2"><nlm:affiliation>Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston 77030, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Melanoma Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston 77030, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Kaper, Mathilde" sort="Kaper, Mathilde" uniqKey="Kaper M" first="Mathilde" last="Kaper">Mathilde Kaper</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Mookerjee, Bijoyesh" sort="Mookerjee, Bijoyesh" uniqKey="Mookerjee B" first="Bijoyesh" last="Mookerjee">Bijoyesh Mookerjee</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Legos, Jeffrey J" sort="Legos, Jeffrey J" uniqKey="Legos J" first="Jeffrey J" last="Legos">Jeffrey J. Legos</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, 1 Health Plaza, East Hanover 07936, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Flaherty, Keith T" sort="Flaherty, Keith T" uniqKey="Flaherty K" first="Keith T" last="Flaherty">Keith T. Flaherty</name><affiliation wicri:level="2"><nlm:affiliation>Developmental Therapeutics and Melanoma Programs, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston 02114, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Developmental Therapeutics and Melanoma Programs, Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston 02114, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Dermatology Service, Gustave Roussy Comprehensive Cancer Center and Faculty of Medicine, University Paris-South, F-94805, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Dermatology Service, Gustave Roussy Comprehensive Cancer Center and Faculty of Medicine, University Paris-South, F-94805, Villejuif</wicri:regionArea><wicri:noRegion>94805, Villejuif</wicri:noRegion><wicri:noRegion>94805, Villejuif</wicri:noRegion></affiliation></author></analytic><series><title level="j">European journal of cancer (Oxford, England : 1990)</title><idno type="eISSN">1879-0852</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Female</term><term>Humans</term><term>Imidazoles (administration & dosage)</term><term>L-Lactate Dehydrogenase (metabolism)</term><term>Male</term><term>Melanoma (drug therapy)</term><term>Melanoma (metabolism)</term><term>Melanoma (pathology)</term><term>Middle Aged</term><term>Neoplasm Metastasis (pathology)</term><term>Oximes (administration & dosage)</term><term>Predictive Value of Tests</term><term>Prognosis</term><term>Protein Kinase Inhibitors (therapeutic use)</term><term>Pyridones (administration & dosage)</term><term>Pyrimidinones (administration & dosage)</term><term>Risk Factors</term><term>Survival Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Imidazoles (administration et posologie)</term><term>Inhibiteurs de protéines kinases (usage thérapeutique)</term><term>L-Lactate dehydrogenase (métabolisme)</term><term>Mâle</term><term>Mélanome (anatomopathologie)</term><term>Mélanome (métabolisme)</term><term>Mélanome (traitement médicamenteux)</term><term>Métastase tumorale (anatomopathologie)</term><term>Oximes (administration et posologie)</term><term>Pronostic</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Pyridones (administration et posologie)</term><term>Pyrimidinones (administration et posologie)</term><term>Sujet âgé</term><term>Valeur prédictive des tests</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Imidazoles</term><term>Oximes</term><term>Pyridones</term><term>Pyrimidinones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>L-Lactate Dehydrogenase</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Imidazoles</term><term>Oximes</term><term>Pyridones</term><term>Pyrimidinones</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome</term><term>Métastase tumorale</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>L-Lactate dehydrogenase</term><term>Mélanome</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Melanoma</term><term>Neoplasm Metastasis</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term><term>Protein Kinase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mélanome</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de protéines kinases</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prognosis</term><term>Risk Factors</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de survie</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Valeur prédictive des tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Understanding predictors of long-term benefit with currently available melanoma therapies is the key for optimising individualised treatments. A prior pooled analysis of dabrafenib plus trametinib (D + T)-randomised trials (median follow-up, 20.0 months) identified baseline lactate dehydrogenase (LDH) and number of organ sites with metastasis as predictive factors for progression-free (PFS) and overall (OS) survival. However, longer-term follow-up analyses are needed to confirm which patients treated with D + T can achieve maximum benefit.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Grèce</li><li>Israël</li><li>Italie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Russie</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Karlsruhe</li><li>District de Tübingen</li><li>District fédéral central</li><li>Massachusetts</li><li>New Jersey</li><li>Nouvelle-Galles du Sud</li><li>Schleswig-Holstein</li><li>Texas</li><li>Île-de-France</li></region><settlement><li>Heidelberg</li><li>Kiel</li><li>Moscou</li><li>Paris</li><li>Sydney</li><li>Tübingen</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name></region><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><name sortKey="Hauschild, Axel" sort="Hauschild, Axel" uniqKey="Hauschild A" first="Axel" last="Hauschild">Axel Hauschild</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Long, Georgina V" sort="Long, Georgina V" uniqKey="Long G" first="Georgina V" last="Long">Georgina V. Long</name></region></country><country name="Russie"><region name="District fédéral central"><name sortKey="Stroiakovski, Daniil" sort="Stroiakovski, Daniil" uniqKey="Stroiakovski D" first="Daniil" last="Stroiakovski">Daniil Stroiakovski</name></region><name sortKey="Levchenko, Evgeny" sort="Levchenko, Evgeny" uniqKey="Levchenko E" first="Evgeny" last="Levchenko">Evgeny Levchenko</name></country><country name="Pologne"><noRegion><name sortKey="Karaszewska, Boguslawa" sort="Karaszewska, Boguslawa" uniqKey="Karaszewska B" first="Boguslawa" last="Karaszewska">Boguslawa Karaszewska</name></noRegion><name sortKey="Mackiewicz, Andrzej" sort="Mackiewicz, Andrzej" uniqKey="Mackiewicz A" first="Andrzej" last="Mackiewicz">Andrzej Mackiewicz</name><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name></country><country name="Italie"><noRegion><name sortKey="Chiarion Sileni, Vanna" sort="Chiarion Sileni, Vanna" uniqKey="Chiarion Sileni V" first="Vanna" last="Chiarion-Sileni">Vanna Chiarion-Sileni</name></noRegion><name sortKey="Mandala, Mario" sort="Mandala, Mario" uniqKey="Mandala M" first="Mario" last="Mandalà">Mario Mandalà</name></country><country name="Israël"><noRegion><name sortKey="Schachter, Jacob" sort="Schachter, Jacob" uniqKey="Schachter J" first="Jacob" last="Schachter">Jacob Schachter</name></noRegion></country><country name="France"><noRegion><name sortKey="Dutriaux, Caroline" sort="Dutriaux, Caroline" uniqKey="Dutriaux C" first="Caroline" last="Dutriaux">Caroline Dutriaux</name></noRegion><name sortKey="Grob, Jean Jacques" sort="Grob, Jean Jacques" uniqKey="Grob J" first="Jean-Jacques" last="Grob">Jean-Jacques Grob</name><name sortKey="Lebbe, Celeste" sort="Lebbe, Celeste" uniqKey="Lebbe C" first="Céleste" last="Lebbé">Céleste Lebbé</name><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name></country><country name="Grèce"><noRegion><name sortKey="Gogas, Helen" sort="Gogas, Helen" uniqKey="Gogas H" first="Helen" last="Gogas">Helen Gogas</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Haanen, John B A G" sort="Haanen, John B A G" uniqKey="Haanen J" first="John B A G" last="Haanen">John B A G. Haanen</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Nathan, Paul" sort="Nathan, Paul" uniqKey="Nathan P" first="Paul" last="Nathan">Paul Nathan</name></noRegion></country><country name="États-Unis"><region name="Californie"><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name></region><name sortKey="Davies, Michael A" sort="Davies, Michael A" uniqKey="Davies M" first="Michael A" last="Davies">Michael A. Davies</name><name sortKey="Flaherty, Keith T" sort="Flaherty, Keith T" uniqKey="Flaherty K" first="Keith T" last="Flaherty">Keith T. Flaherty</name><name sortKey="Kaper, Mathilde" sort="Kaper, Mathilde" uniqKey="Kaper M" first="Mathilde" last="Kaper">Mathilde Kaper</name><name sortKey="Legos, Jeffrey J" sort="Legos, Jeffrey J" uniqKey="Legos J" first="Jeffrey J" last="Legos">Jeffrey J. Legos</name><name sortKey="Mookerjee, Bijoyesh" sort="Mookerjee, Bijoyesh" uniqKey="Mookerjee B" first="Bijoyesh" last="Mookerjee">Bijoyesh Mookerjee</name><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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